HLA-A74
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HLA-A74 | ||||||||||||||||
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(MHC Class I, A cell surface antigen) | ||||||||||||||||
![]() HLA-A74 | ||||||||||||||||
About | ||||||||||||||||
Protein | transmembrane receptor/ligand | |||||||||||||||
Structure | αβ heterodimer | |||||||||||||||
Subunits | HLA-A*74--, β2-microglobulin | |||||||||||||||
Subtypes | ||||||||||||||||
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Rare alleles | ||||||||||||||||
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Alleles link-out to IMGT/HLA database at EBI |
HLA-A74 (A74) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α74 subset of HLA-A α-chains. For A74, the alpha "A" chain are encoded by the HLA-A*74 allele group and the β-chain are encoded by B2M locus.[1] A74 and A*74 are almost synonymous in meaning. A74 is a split antigen of the broad antigen serotype A19. A74 is a sister serotype of A29, A30, A31, A32, and A33.
A74 is more common in Subsaharan Africa. A74 is a rare HLA-A allele group.
Serotype
A*74 | A74 | A19 | Sample |
allele | % | % | size (N) |
*7401 | 40 | 11 | 119 |
*7403 | 17 | 0 | 29 |
A74 has a poor serotyping rate.
Disease associations
A significant association has been found between A74 and nasal polyposis.[3]
Allele distribution
Study population | Freq. (in %)[4] |
---|---|
Colombia African Black | 11.6 |
Kenya | 9.4 |
Cameroon Beti | 8.3 |
Guinea Bissau | 7.7 |
Kenya Luo | 7.2 |
Burkina Faso Mossi | 6.6 |
South African Natal Zulu | 6.5 |
Cape Verde Southeastern I… | 5.6 |
Uganda Kampala | 5.2 |
Cameroon Yaounde | 5.0 |
Cameroon Bamileke | 4.5 |
USA African America | 4.0 |
Cameroon Sawa | 3.8 |
South Africa Tswana | 3.7 |
Mali Bandiagara | 3.6 |
Iran Baloch | 2.8 |
Zimbabwe Harare Shona | 2.7 |
Zambia Lusaka | 2.3 |
Senegal Niokholo Mandenka | 2.2 |
Burkina Faso Rimaibe | 2.1 |
Tunisia Ghannouch | 1.8 |
Kenya Nandi | 1.7 |
Brazil Parana Mulatto | 1.6 |
Brazil | 1.5 |
Morocco Nador Metalsa Cla… | 1.4 |
Thailand Northeast | 1.2 |
Venezuela Colonia Tovar | 1.2 |
Brazil Belo Horizonte | 1.1 |
Thailand | 1.1 |
Tunisia Tunis | 1.1 |
Turkey (1) | 1.1 |
Allele frequencies presented, only |
Study population | Freq. (in %)[4] |
---|---|
Kenya Luo | 2.8 |
Argentina Toba Rosario | 0.6 |
Iran Baloch | 0.6 |
Saudi Arabia Guraiat and … | 0.5 |
Kenya | 0.3 |
Madeira | 0.3 |
Uganda Kampala | 0.3 |
Allele frequencies presented, only |
Sources
- Madrigal JA, Belich MP, Hildebrand WH, et al. (November 1992). "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion" (PDF). J. Immunol. 149 (10): 3411–5. PMID 1431115.[permanent dead link]
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ Luxenberger W, Posch U, Berghold A, Hofmann T, Lang-Loidolt D (2000). "HLA patterns in patients with nasal polyposis". European Archives of Oto-Rhino-Laryngology. 257 (3): 137–9. doi:10.1007/s004050050210. PMID 10839486.
- ^ a b Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.