HLA-A29
Jump to navigation
Jump to search
HLA-A29 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
(MHC Class I, A cell surface antigen) | ||||||||||||||||
![]() HLA-A29 | ||||||||||||||||
About | ||||||||||||||||
Protein | transmembrane receptor/ligand | |||||||||||||||
Structure | αβ heterodimer | |||||||||||||||
Subunits | HLA-A*29--, β2-microglobulin | |||||||||||||||
Older names | A19 | |||||||||||||||
Subtypes | ||||||||||||||||
| ||||||||||||||||
Alleles link-out to IMGT/HLA database at EBI |
HLA-A29 (A29) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α29 subset of HLA-A α-chains. For A29, the alpha "A" chain are encoded by the HLA-A*29 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2902. A29 and A*29 are almost synonymous in meaning. A29 is a split antigen of the broad antigen serotype A19. A29 is a sister serotype of A30, A31, A32, A33, and A74.
A29 is more common in Western Africa and Southwestern Europe.
Serotype
A*29 | A29 | Sample |
allele | % | size (N) |
*2901 | 96 | 119 |
*2902 | 99 | 1148 |
Allele distribution
Study population | Freq. (in %)[3] |
---|---|
Spain Pas Valley | 13.5 |
Spain Basque Gipuzkoa Pro… | 12.5 |
South Africa Tswana | 12.2 |
South African Natal Zulu | 11.0 |
Cameroon Yaounde | 10.4 |
Cameroon Pygmy Baka | 10.0 |
Zimbabwe Harare Shona | 9.6 |
Burkina Faso Fulani | 9.5 |
Spain Catalonia Girona | 9.3 |
Spain Ibizans | 9.3 |
Tunisia Ghannouch | 9.1 |
Saudi Arabia | 8.7 |
Cameroon Bamileke | 8.4 |
Cameroon Bakola Pygmy | 8.3 |
Spain Murcia | 8.3 |
Spain Menorca | 8.2 |
Spain Basque Arratia Vall… | 8.0 |
Cameroon Sawa | 7.7 |
Spain North Cabuernigo | 7.7 |
Tunisia | 7.2 |
Portugal Centre | 7.0 |
Spain Eastern Andalusia | 6.9 |
Tunisia | 6.7 |
Cameroon Beti | 6.3 |
France Corsica | 6.0 |
Scotland Orkney | 6.0 |
Spain North Cantabrian | 6.0 |
Zambia Lusaka | 5.8 |
Kenya Luo | 5.3 |
England Liverpool | 5.2 |
France South East | 5.1 |
Ireland Northern | 4.9 |
Kenya | 4.9 |
Tunisia Tunis | 4.9 |
USA Hispanic | 4.9 |
Kenya Nandi | 4.8 |
Mongolia Hoton | 4.8 |
Mongolia Khoton Tarialan | 4.8 |
England Manchester | 4.8 |
England Newcastle | 4.7 |
Pakistan Karachi Parsi | 4.4 |
USA Caucasian (2) | 4.3 |
Morocco 'berber' Nador Me… | 4.1 |
Israeli Jews | 3.9 |
England Lancaster | 3.8 |
India Jalpaiguri Toto | 3.8 |
Senegal Niokholo Mandenka | 3.8 |
Belgium | 3.7 |
Italy | 3.6 |
Wales | 3.6 |
Morocco | 3.4 |
Mali Bandiagara | 3.3 |
Ireland South | 3.2 |
Uganda Kampala | 3.1 |
Australia New South Wales | 3.0 |
Brazil | 3.0 |
Macedonia (4) | 3.0 |
China Yunnan Han (2) | 2.9 |
Greece (3) | 2.9 |
India North Delhi | 2.7 |
Peru Arequipa | 2.7 |
Taiwan Hakka | 2.7 |
USA North American Native… | 2.7 |
Italy South Campania | 2.6 |
Italy Bergamo | 2.6 |
Algeria1 | 2.5 |
India Kerala Hindu Nair | 2.4 |
Israel Gaza Palestinians | 2.4 |
Mexico Mestizos | 2.4 |
Guatemala Mayans | 2.3 |
German Essen | 2.0 |
India West Coast Parsis | 2.0 |
Israel Arab Druse | 2.0 |
Romanian | 1.9 |
Sudanese | 1.8 |
Pakistan Brahui | 1.7 |
Thailand Northeast | 1.6 |
China Harbin Man | 1.5 |
Guinea Bissau | 1.5 |
Italy Sardinia pop3 | 1.5 |
Mexico Sonora Seri | 1.5 |
Pakistan Pathan | 1.5 |
Turkey | 1.3 |
Czech Republic | 1.4 |
Sweden Stockholm | 1.4 |
Oman | 1.3 |
Sweden Uppsala County | 1.2 |
Russia Nenets | 1.2 |
Allele frequencies presented, only |
Study population | Freq. (in %)[3] |
---|---|
Georgia Tbilisi Kurds | 6.7 |
Mexico Guadalajara Mestiz… | 6.3 |
CAR Mbenzele Pygmy | 5.7 |
Israel Arab Druse | 4.5 |
Pakistan Karachi Parsi | 4.4 |
Iran Baloch | 2.8 |
Taiwan Hakka | 2.7 |
Kenya | 2.1 |
Saudi Arabia Guraiat and … | 2.1 |
India West Coast Parsis | 2.0 |
India North Hindus | 1.9 |
Jordan Amman | 1.7 |
Pakistan Brahui | 1.7 |
China Guangzhou | 1.5 |
India New Delhi | 1.5 |
Pakistan Pathan | 1.5 |
Singapore Thai | 1.5 |
South African Natal Zulu | 1.5 |
Georgia Svaneti Svans | 1.3 |
Kenya Nandi | 1.3 |
USA Asian | 1.3 |
China South Han | 1.2 |
Finland | 1.1 |
India North Delhi | 1.1 |
Kenya Luo | 1.1 |
China Inner Mongolia | 1.0 |
Portugal Centre | 1.0 |
South Korea (3) | 1.0 |
Pakistan Baloch | 0.8 |
Croatia | 0.7 |
Thailand | 0.7 |
Ireland South | 0.6 |
Romanian | 0.6 |
Uganda Kampala | 0.6 |
USA San Antonio Caucasian… | 0.6 |
Allele frequencies presented, only |
Haplotypes
For A29-Cw*16-B44 (A*2902:Cw*1601:B*4403) haplotype see Cw*16
References
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
- ^ a b Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.