Zinc finger and scan domain containing 4
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Zinc finger and SCAN domain containing 4 is a protein that in humans is encoded by the ZSCAN4 gene. [1]
Function
The ZSCAN4 gene encodes a protein involved in telomere maintenance and with a key role in the critical feature of mouse embryonic stem cells, namely, defying cellular senescence and maintaining normal karyotype for many cell divisions in culture.[2]
References
- ^ "Entrez Gene: Zinc finger and SCAN domain containing 4". Retrieved 2017-06-05.
- ^ Ko, Minoru S. H.; Wersto, Robert P.; Indig, Fred E.; Yang, Hsih-Te; Hoang, Hien G.; Carole A. Stagg; Lee, Sung-Lim; Thomas, Marshall; Nishiyama, Akira (April 2010). "Zscan4 regulates telomere elongation and genomic stability in ES cells". Nature. 464 (7290): 858–863. Bibcode:2010Natur.464..858Z. doi:10.1038/nature08882. ISSN 1476-4687. PMC 2851843. PMID 20336070.
Further reading
- Lee K, Gollahon LS (2014). "Zscan4 interacts directly with human Rap1 in cancer cells regardless of telomerase status". Cancer Biol. Ther. 15 (8): 1094–105. doi:10.4161/cbt.29220. PMC 4119077. PMID 24840609.
- Lee K, Gollahon LS (2015). "ZSCAN4 and TRF1: A functionally indirect interaction in cancer cells independent of telomerase activity". Biochem. Biophys. Res. Commun. 466 (4): 644–9. doi:10.1016/j.bbrc.2015.09.107. PMID 26403970.
- Ishiguro KI, Nakatake Y, Chikazawa-Nohtomi N, Kimura H, Akiyama T, Oda M, Ko SB, Ko MS (2017). "Expression analysis of the endogenous Zscan4 locus and its coding proteins in mouse ES cells and preimplantation embryos". In Vitro Cell. Dev. Biol. Anim. 53 (2): 179–190. doi:10.1007/s11626-016-0097-y. PMC 5311086. PMID 27699651.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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