Vasculogenic mimicry
Vasculogenic mimicry is the formation of microvascular channels by aggressive, metastatic and genetically deregulated tumour cells.[1][2][3] This process differs from angiogenesis in that it occurs de novo without the presence of endothelial cells (tumour cells line tumour vessels effectively mimicking a true vascular endothelium).[3] It was first described in uveal melanomas by Maniotis et al. in 1999.[4] There are two main types of vasculogenic mimicry: tubular and patterned. The former is morphologically similar to normal blood vessels, whereas the latter is visibly different although capable of undergoing anastomosis with blood vessels.[2]
The microvasculature generated through vasculogenic mimicry contains a basement membrane that stains positive with periodic acid–Schiff stain.[1]
History
After its discovery in 1999 a controversy arose in the field regarding the validity of the findings and conclusions of Maniotis and colleagues.[5] Nonetheless, their findings have been further supported by several research groups, becoming the focus of much interest due to its potential role as a therapeutic target and indicator of metastasis.[6]
See also
References
- ^ a b Folberg, R; Hendrix, MJ; Maniotis, AJ (February 2000). "Vasculogenic mimicry and tumor angiogenesis". The American Journal of Pathology. 156 (2): 361–81. doi:10.1016/s0002-9440(10)64739-6. PMC 1850026. PMID 10666364.
- ^ a b Folberg, R; Maniotis, AJ (July–August 2004). "Vasculogenic mimicry". APMIS. 112 (7–8): 508–25. doi:10.1111/j.1600-0463.2004.apm11207-0810.x. PMID 15563313. S2CID 84526027.
- ^ a b Milosevic, Vladan; Edelmann, Reidunn J.; Fosse, Johanna Hol; Östman, Arne; Akslen, Lars A. (2022), Akslen, Lars A.; Watnick, Randolph S. (eds.), "Molecular Phenotypes of Endothelial Cells in Malignant Tumors", Biomarkers of the Tumor Microenvironment, Cham: Springer International Publishing, pp. 31–52, doi:10.1007/978-3-030-98950-7_3, ISBN 978-3-030-98950-7, retrieved 2022-07-13
- ^ Maniotis, AJ; Folberg, R; Hess, A; Seftor, EA; Gardner, LM; Pe'er, J; Trent, JM; Meltzer, PS; Hendrix, MJ (September 1999). "Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry". The American Journal of Pathology. 155 (3): 739–52. doi:10.1016/s0002-9440(10)65173-5. PMC 1866899. PMID 10487832.
- ^ Fausto, Nelson (February 2000). "Vasculogenic Mimicry in Tumors". The American Journal of Pathology. 156 (2): 359. doi:10.1016/S0002-9440(10)64738-4. PMC 1850025. PMID 10666363.
- ^ Seftor, RE; Hess, AR; Seftor, EA; Kirschmann, DA; Hardy, KM; Margaryan, NV; Hendrix, MJ (October 2012). "Tumor cell vasculogenic mimicry: from controversy to therapeutic promise". The American Journal of Pathology. 181 (4): 1115–25. doi:10.1016/j.ajpath.2012.07.013. PMC 4851740. PMID 22944600.
Further reading
- Milosevic, V., Edelmann, R.J., Fosse, J.H., Östman, A., Akslen, L.A. (2022). Molecular Phenotypes of Endothelial Cells in Malignant Tumors. In: Akslen, L.A., Watnick, R.S. (eds) Biomarkers of the Tumor Microenvironment. Springer, Cham. https://doi.org/10.1007/978-3-030-98950-7_3
- Fan, Yu-Long; Zheng, Min; Ya-Ling, Tan; Liang, Xin‑Hua (August 2013). "A new perspective of vasculogenic mimicry: EMT and cancer stem cells (Review)". Oncology Letters. 6 (5): 1174–1180. doi:10.3892/ol.2013.1555. PMC 3813799. PMID 24179490.
- Kirschmann, D. A.; Seftor, E. A.; Hardy, K. M.; Seftor, R. E. B.; Hendrix, M. J. C. (April 2012). "Molecular Pathways: Vasculogenic Mimicry in Tumor Cells: Diagnostic and Therapeutic Implications". Clinical Cancer Research. 18 (10): 2726–2732. doi:10.1158/1078-0432.CCR-11-3237. PMC 3354024. PMID 22474319.
- Qiao, Lili; Liang, Ning; Zhang, Jiandong; Xie, Jian; Liu, Fengjun; Xu, Deguo; Yu, Xinshuang; Tian, Yuan (February 2015). "Advanced research on vasculogenic mimicry in cancer". Journal of Cellular and Molecular Medicine. 19 (2): 315–326. doi:10.1111/jcmm.12496. PMC 4407602. PMID 25598425.