Trypanotolerance
A trypanotolerant organism is one which is relatively less affected by trypanosome infestation.
By host
In humans
In livestock
Some breeds are known for their trypanotolerance. This is especially important in Africa where a few particular trypanosomes are major economic and agricultural pests.[1][2][3][4]
Trypanotolerant livestock breeds
- N'Dama cattle[2]
- West African Dwarf goats[5]: 106
- West African Dwarf sheep (Djallonké)[6]
- Cameroon sheep
History of genetic research
Trypanotolerance had previously been achieved through normal livestock breeding in cattle, but genetic analysis was becoming a serious option in the 1980s. The effort that would eventually bear fruit began with a conversation between Peter Brumby - then at the International Livestock Centre for Africa - and Morris Soller in 1985. This was followed by the opening of the shortlived International Trypanotolerance Center in the Gambia in 1987 with a seminar on the genome mapping project that would continue beyond the Center itself. The project was then actually completed by the ILRI - the successor to the ILCA - in 2003.[7]
References
- ^ D'IETEREN, G.D.M.; AUTHIE, E.; WISSOCQ, N.; MURRAY, M. (1998-04-01). "Trypanotolerance, an option for sustainable livestock production in areas at risk from trypanosomosis". Revue Scientifique et Technique de l'OIE. O.I.E (World Organisation for Animal Health). 17 (1): 154–175. doi:10.20506/rst.17.1.1088. ISSN 0253-1933. PMID 9638808.
- ^ a b Kim, Soo-Jin; Ka, Sojeong; Ha, Jung-Woo; Kim, Jaemin; Yoo, DongAhn; Kim, Kwondo; Lee, Hak-Kyo; Lim, Dajeong; Cho, Seoae; Hanotte, Olivier; Mwai, Okeyo Ally; Dessie, Tadelle; Kemp, Stephen; Oh, Sung Jong; Kim, Heebal (2017-05-12). "Cattle genome-wide analysis reveals genetic signatures in trypanotolerant N'Dama". BMC Genomics. BioMed Central/Springer Science and Business Media LLC. 18 (1). doi:10.1186/s12864-017-3742-2. ISSN 1471-2164.
- ^ "Trypanotolerant livestock in the context of trypanosomiasis intervention strategies". Food and Agriculture Organization of the United Nations. Retrieved 2021-02-20.
- ^ "Trypanotolerance in West African cattle". CIRAD (Centre de coopération internationale en recherche agronomique pour le développement). Retrieved 2021-02-20.
- ^ R. T. Wilson (1991). Small Ruminant Production and the Small Ruminant Genetic Resource in Tropical Africa Rome: Food and Agriculture Organization of the United Nations. ISBN 9789251029985.
- ^ "HAUT DEGRE DE TOLERANCE A LA TRYPANOSOMOSE DES MOUTONS ET DES CHEVRES DE RACE NAINE DJALLONKE DES REGIONS SUD-GUINEENNES DU TOGO : COMPARAISON AVEC DES BOVINS TRYPANOTOLERANTS". Revue d'élevage et de médecine vétérinaire des pays tropicaux. 1987. doi:10.19182/REMVT.8696. PMID 3444966. S2CID 86116225.
- ^ Soller, Morris (2015-02-16). "If a Bull Were a Cow, How Much Milk Would He Give?". Annual Review of Animal Biosciences. Annual Reviews. 3 (1): 1–17. doi:10.1146/annurev-animal-022114-110751. ISSN 2165-8102.
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