Sodium calcium edetate
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Trade names | Calcium disodium versenate, others |
Other names | edetate calcium disodium, sodium calcium edetate |
AHFS/Drugs.com | Monograph |
Routes of administration | IV, IM |
Drug class | chelating agent |
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Chemical and physical data | |
Formula | C10H12CaN2Na2O8 |
Molar mass | 374.270 g·mol−1 |
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Sodium calcium edetate (sodium calcium EDTA), also known as edetate calcium disodium among other names, is a medication primarily used to treat lead poisoning,[1] including both short-term and long-term lead poisoning.[2] Sodium calcium edetate came into medical use in the United States in 1953.[2]
Chelation agent
Sodium calcium edetate is in the chelating agent family of medication.[2] It is a salt of edetate with two sodium and one calcium atoms.[3] It works by binding to a number of heavy metals, which renders them almost inert and allows them to leave the body in the urine.[2]
Edetate disodium is a different formulation which does not have the same effects.[2]
Medical use
Sodium calcium edetate's primary use is to treat lead poisoning,[1] for which it is an alternative to succimer.[2] It is given by slow injection into a vein or into a muscle.[1]
For lead encephalopathy sodium calcium edetate is typically used together with dimercaprol.[2] It may also be used to treat plutonium poisoning.[4] It does not appear to be useful for poisoning by tetra-ethyl lead.[2]
Side effects
Common side effects include pain at the site of injection.[2] Other side effects may include kidney problems, diarrhea, fever, muscle pains, and low blood pressure.[1] Benefits when needed in pregnancy are likely greater than the risks.[2]
History
Sodium calcium edetate came into medical use in the United States in 1953.[2] It is on the World Health Organization's List of Essential Medicines.[5]
References
- ^ a b c d Stuart MC, Kouimtzi M, Hill SR, eds. (2009). WHO Model Formulary 2008. World Health Organization. pp. 59, 62, 65. hdl:10665/44053. ISBN 9789241547659.
- ^ a b c d e f g h i j k "Edetate Calcium Disodium". The American Society of Health-System Pharmacists. Archived from the original on 16 January 2017. Retrieved 8 January 2017.
- ^ Kasture AV (2008). Pharmaceutical Chemistry. Vol. I. Pragati Books Pvt. Ltd. p. 16.11. ISBN 9788185790121. Archived from the original on 16 January 2017.
- ^ Flanagan R, Jones A, Maynard RL (2003). Antidotes: Principles and Clinical Applications. CRC Press. p. 47. ISBN 9780203485071. Archived from the original on 16 January 2017.
- ^ World Health Organization model list of essential medicines: 21st list 2019. Geneva,CH: World Health Organization. 2019. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
External links
- "Sodium calcium edetate". U.S. National Library of Medicine. Drug Information Portal. U.S. National Institutes of Health.