PTENP1
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An Error has occurred retrieving Wikidata item for infobox Phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1, also known as PTENP1, is a human pseudogene.[1] which has a partial reactivated function as a competing endogenous RNA regulating the tumor suppressor gene PTEN.[2]
References
- ^ "Entrez Gene: PTENP1 phosphatase and tensin homolog (mutated in multiple advanced cancers 1), pseudogene 1".
- ^ Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP (June 2010). "A coding-independent function of gene and pseudogene mRNAs regulates tumour biology". Nature. 465 (7301): 1033–8. Bibcode:2010Natur.465.1033P. doi:10.1038/nature09144. PMC 3206313. PMID 20577206.*Lay summary in: Buehler J (September 1, 2021). "The Complex Truth About 'Junk DNA'". Quanta Magazine.
Further reading
- Kong D, Suzuki A, Zou TT, Sakurada A, Kemp LW, Wakatsuki S, et al. (October 1997). "PTEN1 is frequently mutated in primary endometrial carcinomas". Nature Genetics. 17 (2): 143–4. doi:10.1038/ng1097-143. PMID 9326929. S2CID 29666790.
- Teng DH, Hu R, Lin H, Davis T, Iliev D, Frye C, et al. (December 1997). "MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines". Cancer Research. 57 (23): 5221–5. PMID 9393738.
- Sakurada A, Suzuki A, Sato M, Yamakawa H, Orikasa K, Uyeno S, et al. (November 1997). "Infrequent genetic alterations of the PTEN/MMAC1 gene in Japanese patients with primary cancers of the breast, lung, pancreas, kidney, and ovary". Japanese Journal of Cancer Research. 88 (11): 1025–8. doi:10.1111/j.1349-7006.1997.tb00324.x. PMC 5921310. PMID 9439675.
- Kim SK, Su LK, Oh Y, Kemp BL, Hong WK, Mao L (January 1998). "Alterations of PTEN/MMAC1, a candidate tumor suppressor gene, and its homologue, PTH2, in small cell lung cancer cell lines". Oncogene. 16 (1): 89–93. doi:10.1038/sj.onc.1201512. PMID 9467947.
- Dahia PL, FitzGerald MG, Zhang X, Marsh DJ, Zheng Z, Pietsch T, et al. (May 1998). "A highly conserved processed PTEN pseudogene is located on chromosome band 9p21". Oncogene. 16 (18): 2403–6. doi:10.1038/sj.onc.1201762. PMID 9620558.
- Forgacs E, Biesterveld EJ, Sekido Y, Fong K, Muneer S, Wistuba II, et al. (September 1998). "Mutation analysis of the PTEN/MMAC1 gene in lung cancer". Oncogene. 17 (12): 1557–65. doi:10.1038/sj.onc.1202070. PMID 9794233. S2CID 24423191.
- Fujii GH, Morimoto AM, Berson AE, Bolen JB (March 1999). "Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN". Oncogene. 18 (9): 1765–9. doi:10.1038/sj.onc.1202492. PMID 10208437.
- Trojan J, Plotz G, Brieger A, Raedle J, Meltzer SJ, Wolter M, Zeuzem S (December 2001). "Activation of a cryptic splice site of PTEN and loss of heterozygosity in benign skin lesions in Cowden disease". The Journal of Investigative Dermatology. 117 (6): 1650–3. doi:10.1046/j.0022-202x.2001.01954.x. PMID 11886535.
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