OR52D1
An Error has occurred retrieving Wikidata item for infobox Olfactory receptor 52D1 is a protein that in humans is encoded by the OR52D1 gene.[1]
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]
Ligands
Compared to other olfactory receptors such as OR1G1, OR52D1 has a more narrow/specific range of ligands.[2]
Agonists:
- Methyl octanoate[2]
- "Better activated by acids, aldehydes, ketones and esters than alcohols or pyrazines"[2]
See also
References
- ^ a b "Entrez Gene: OR52D1 olfactory receptor, family 52, subfamily D, member 1".
- ^ a b c Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.
Further reading
- Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, et al. (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
- Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, et al. (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
- Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
- OR52D1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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