Mucin 5AC
An Error has occurred retrieving Wikidata item for infobox Mucin 5AC (Muc5AC) is a protein that in humans is encoded by the MUC5AC gene.[1][2][3]
Muc5AC is a large gel-forming glycoprotein. In the respiratory tract it protects against infection by binding to inhaled pathogens that are subsequently removed by mucociliary clearance. Overproduction of Muc5AC can contribute to diseases such as asthma and chronic obstructive pulmonary disease,[4] and has also been associated with greater protection against influenza infection.[5]
Clinical relevance
This gene has been linked to mucus hypersecretion in the respiratory tract and is associated to chronic obstructive pulmonary disease (COPD).[6]
References
- ^ Guyonnet Duperat V, Audie JP, Debailleul V, Laine A, Buisine MP, Galiegue-Zouitina S, Pigny P, Degand P, Aubert JP, Porchet N (Feb 1995). "Characterization of the human mucin gene MUC5AC: a consensus cysteine-rich domain for 11p15 mucin genes?". Biochem J. 305 (Pt 1): 211–9. doi:10.1042/bj3050211. PMC 1136451. PMID 7826332.
- ^ van de Bovenkamp JH, Hau CM, Strous GJ, Buller HA, Dekker J, Einerhand AW (Jun 1998). "Molecular cloning of human gastric mucin MUC5AC reveals conserved cysteine-rich D-domains and a putative leucine zipper motif". Biochem Biophys Res Commun. 245 (3): 853–9. doi:10.1006/bbrc.1998.8535. PMID 9588204.
- ^ "Entrez Gene: MUC5AC mucin 5AC, oligomeric mucus/gel-forming".
- ^ Samsuzzaman M, Uddin MS, Shah MA, Mathew B (August 2019). "Natural inhibitors on airway mucin: Molecular insight into the therapeutic potential targeting MUC5AC expression and production". Life Sciences. 231: 116485. doi:10.1016/j.lfs.2019.05.041. PMID 31116959. S2CID 162182150.
- ^ Ehre, Camille; Worthington, Erin N.; Liesman, Rachael M.; Grubb, Barbara R.; Barbier, Diane; O'Neal, Wanda K.; Sallenave, Jean-Michel; Pickles, Raymond J.; Boucher, Richard C. (2012-10-09). "Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs". Proceedings of the National Academy of Sciences of the United States of America. 109 (41): 16528–16533. doi:10.1073/pnas.1206552109. ISSN 1091-6490. PMC 3478656. PMID 23012413.
- ^ Li J, Ye Z (September 2020). "The Potential Role and Regulatory Mechanisms of MUC5AC in Chronic Obstructive Pulmonary Disease". Molecules. Basel, Switzerland. 25 (19): 4437. doi:10.3390/molecules25194437. PMC 7582261. PMID 32992527.
External links
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Mucin-5AC
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