Kevan Shokat
Kevan Michael Shokat | |
---|---|
Born | Boulder City, Nevada, USA | August 26, 1964
Nationality | American |
Alma mater | Reed College University of California, Berkeley |
Known for | Kinase signaling |
Scientific career | |
Fields | Chemical biology |
Institutions | Princeton University University of California, San Francisco |
Doctoral advisor | Peter G. Schultz |
Other academic advisors | Christopher Goodnow |
Kevan Michael Shokat (born August 26, 1964)[1] is an American chemical biologist. He is a Professor and Chair in the Department of Cellular and Molecular Pharmacology at University of California, San Francisco, a Professor in the Department of Chemistry at University of California, Berkeley, and an Investigator with the Howard Hughes Medical Institute.
Biography
Shokat received his B.A, in chemistry from Reed College in 1986, completing his thesis, "Synthesis of a precursor of PRCPCP, a non-hydrolyzable analog of phosphoribosylpyrophosphate (PRPP)," with Ron McClard, and his Ph.D. from University of California, Berkeley in 1991, under Peter G. Schultz.
Research
Shokat is one of the leading figures in the field of chemical genetics.[2] He uses methods of bioorganic chemistry to elucidate signal transduction pathways at the single cell and whole organism levels, and is particularly interested in protein kinases, and developing methods to elucidate the particular targets of each kinase, such as the Bump and hole method.
In 2013 Shokat published the first covalent inhibitors of KRAS G12C using a tethering screen.[3] Following this strategy many pharma companies have developed KRAS programs leading to phase I/II clinical trials in this space, a landmark for what was once thought to be an undruggable oncogene.
Honors and awards
- 2002 Eli Lilly Award in Biological Chemistry[4]
- 2009 Elected to the National Academy of Sciences[5]
- 2011 Elected to the American Academy of Arts and Sciences[6]
- 2017 Pharmacology Krebs Lecture, University of Washington
References
- ^ "Oral history interview with Kevan M. Shokat". Science History Institute Digital Collections. Retrieved 2022-08-21.
- ^ "Kevan Shokat at the Michael j. Fox foundation". Retrieved 1 February 2017.
- ^ Ostrem, Jonathan M.; Peters, Ulf; Sos, Martin L.; Wells, James A.; Shokat, Kevan M. (November 2013). "K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions". Nature. 503 (7477): 548–551. Bibcode:2013Natur.503..548O. doi:10.1038/nature12796. PMC 4274051. PMID 24256730.
- ^ Eli Lilly Award in Biological Chemistry, Prizewinners 1935 - 2017, retrieved 1/26/2017
- ^ Kevan M. Shokat, at National Academy of Sciences (nasonline.org), retrieved 1/26/2017
- ^ Book of Members 1780–present , Members of the American Academy of Arts & Sciences, 1780-2016, retrieved 1/26/2017
External links
- Articles without Wikidata item
- Articles with hCards
- AC with 0 elements
- American medical researchers
- Reed College alumni
- Howard Hughes Medical Investigators
- 1964 births
- Living people
- University of California, Berkeley alumni
- University of California, San Francisco faculty
- Members of the National Academy of Medicine
- Princeton University faculty
- All stub articles
- American academic biography stubs