Jesse D. Bloom

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Jesse D. Bloom is an American computational virologist and Professor in the Basic Sciences Division, the Public Health Sciences Division, and the Herbold Computational Biology Program, at the Fred Hutchinson Cancer Center.[1] He is also an Investigator of the Howard Hughes Medical Institute, and an Affiliate Professor in the University of Washington departments of Genome Sciences and Microbiology.[2][3][4]

Education and career

Bloom obtained a B.S. in Biochemistry from the University of Chicago, an M.Phil. in Theoretical Chemistry from the University of Cambridge, and a Ph.D in Chemistry from Caltech advised by Frances Arnold.[1] Following his Ph.D., he completed a postdoctoral fellowship in the laboratory of David Baltimore.[5]

Bloom’s research focuses on the molecular evolution of viruses and viral proteins, particularly of rapidly-evolving RNA viruses like Influenza, HIV, and SARS-CoV-2.[1][6][7][8] His lab uses a combination of computational and experimental techniques to understand how changes in viral proteins result in immune escape, drug resistance, and shifts in host specificity.[2]

Bloom has pioneered techniques for measuring the effects of large numbers of mutations in viral proteins in parallel.[6][8][9] Notably, his laboratory provided one of the earliest maps of the effects of mutations in the SARS-CoV-2 spike receptor binding domain on folding and ACE2 affinity.[8] Using the same technique, Bloom’s research group prospectively identified mutations in the SARS-CoV-2 spike protein that erode the immunity provided by both therapeutic antibodies and naturally elicited immune responses.[10][11]

In 2021, Bloom was a co-author of a letter calling for further investigation of COVID-19 origins published in Science.[12] Bloom's research on the origin of COVID-19 "raised the possibility that the Chinese government might be trying to hide evidence about the pandemic’s early spread" and was the subject of a meeting with Anthony Fauci, the director of the National Institute of Allergy and Infectious Diseases (NIAID).[13]

Bloom has been published in Science, Nature, and Cell.[10][14][8]

Honors and awards

  • 2016 HHMI-Simons Faculty Scholar[15]
  • 2018 HHMI Investigator[16]

External links

References

  1. ^ a b c "Jesse Bloom, Ph.D." Fred Hutch. Retrieved 2022-05-18.
  2. ^ a b "Jesse D. Bloom". HHMI. Retrieved 2022-10-29.
  3. ^ "Jesse D. Bloom | UW Microbiology". microbiology.washington.edu. Retrieved 2022-10-29.
  4. ^ "UW Genome Sciences: Jesse Bloom". www.gs.washington.edu. Retrieved 2022-10-29.
  5. ^ "Jesse Bloom". www.aiche.org. 2021-03-05. Retrieved 2022-10-29.
  6. ^ a b Thyagarajan, Bargavi; Bloom, Jesse D (2014-07-08). Pascual, Mercedes (ed.). "The inherent mutational tolerance and antigenic evolvability of influenza hemagglutinin". eLife. 3: e03300. doi:10.7554/eLife.03300. ISSN 2050-084X. PMC 4109307. PMID 25006036.
  7. ^ Haddox, Hugh K.; Dingens, Adam S.; Bloom, Jesse D. (2016-12-13). "Experimental Estimation of the Effects of All Amino-Acid Mutations to HIV's Envelope Protein on Viral Replication in Cell Culture". PLOS Pathogens. 12 (12): e1006114. doi:10.1371/journal.ppat.1006114. ISSN 1553-7374. PMC 5189966. PMID 27959955.
  8. ^ a b c d Starr, Tyler N.; Greaney, Allison J.; Hilton, Sarah K.; Ellis, Daniel; Crawford, Katharine H. D.; Dingens, Adam S.; Navarro, Mary Jane; Bowen, John E.; Tortorici, M. Alejandra; Walls, Alexandra C.; King, Neil P.; Veesler, David; Bloom, Jesse D. (2020-09-03). "Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding". Cell. 182 (5): 1295–1310.e20. doi:10.1016/j.cell.2020.08.012. ISSN 0092-8674. PMC 7418704. PMID 32841599.
  9. ^ Dadonaite, Bernadeta; Crawford, Katharine H. D.; Radford, Caelan E.; Farrell, Ariana G.; Yu, Timothy C.; Hannon, William W.; Zhou, Panpan; Andrabi, Raiees; Burton, Dennis R.; Liu, Lihong; Ho, David D.; Neher, Richard A.; Bloom, Jesse D. (2022-10-13). "A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike": 2022.10.13.512056. doi:10.1101/2022.10.13.512056. PMC 9580381. PMID 36263061. {{cite journal}}: Cite journal requires |journal= (help)
  10. ^ a b Starr, Tyler N.; Greaney, Allison J.; Addetia, Amin; Hannon, William W.; Choudhary, Manish C.; Dingens, Adam S.; Li, Jonathan Z.; Bloom, Jesse D. (2021-02-19). "Prospective mapping of viral mutations that escape antibodies used to treat COVID-19". Science. 371 (6531): 850–854. doi:10.1126/science.abf9302. ISSN 0036-8075. PMC 7963219. PMID 33495308.
  11. ^ Greaney, Allison J.; Loes, Andrea N.; Crawford, Katharine H. D.; Starr, Tyler N.; Malone, Keara D.; Chu, Helen Y.; Bloom, Jesse D. (2021-03-10). "Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies". Cell Host & Microbe. 29 (3): 463–476.e6. doi:10.1016/j.chom.2021.02.003. ISSN 1931-3128. PMC 7869748. PMID 33592168.
  12. ^ Bloom, Jesse D.; Chan, Yujia Alina; Baric, Ralph S.; Bjorkman, Pamela J.; Cobey, Sarah; Deverman, Benjamin E.; Fisman, David N.; Gupta, Ravindra; Iwasaki, Akiko; Lipsitch, Marc; Medzhitov, Ruslan; Neher, Richard A.; Nielsen, Rasmus; Patterson, Nick; Stearns, Tim (2021-05-14). Sills, Jennifer (ed.). "Investigate the origins of COVID-19". Science. 372 (6543): 694–694. doi:10.1126/science.abj0016. ISSN 0036-8075. PMC 9520851. PMID 33986172.
  13. ^ ""This Shouldn't Happen": Inside the Virus-Hunting Nonprofit at the Center of the Lab-Leak Controversy". Vanity Fair. 2022-03-31. Retrieved 2022-05-18.
  14. ^ Starr, Tyler N.; Czudnochowski, Nadine; Liu, Zhuoming; Zatta, Fabrizia; Park, Young-Jun; Addetia, Amin; Pinto, Dora; Beltramello, Martina; Hernandez, Patrick; Greaney, Allison J.; Marzi, Roberta; Glass, William G.; Zhang, Ivy; Dingens, Adam S.; Bowen, John E. (September 2021). "SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape". Nature. 597 (7874): 97–102. doi:10.1038/s41586-021-03807-6. ISSN 1476-4687.
  15. ^ "People". Simons Foundation. Retrieved 2022-10-29.
  16. ^ "Jesse Bloom, PhD". HHMI. Retrieved 2022-10-29.


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