FKBP8

An Error has occurred retrieving Wikidata item for infobox FK506-binding protein 8 is a protein that in humans is encoded by the FKBP8 gene.^[1]^[2]

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. Unlike the other members of the family, this encoded protein does not seem to have PPIase/rotamase activity. It may have a role in neurons associated with memory function.^[2]

References

^ Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.
^ ^a ^b "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

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Shirane M, Nakayama KI (2003). "Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis". Nat. Cell Biol. 5 (1): 28–37. doi:10.1038/ncb894. PMID 12510191. S2CID 11653096.
Rosner M, Hofer K, Kubista M, Hengstschläger M (2003). "Cell size regulation by the human TSC tumor suppressor proteins depends on PI3K and FKBP38". Oncogene. 22 (31): 4786–98. doi:10.1038/sj.onc.1206776. PMID 12894220.
Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.
Bulgakov OV, Eggenschwiler JT, Hong DH, et al. (2004). "FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues". Development. 131 (9): 2149–59. doi:10.1242/dev.01122. PMID 15105374.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
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Kang CB, Tai J, Chia J, Yoon HS (2005). "The flexible loop of Bcl-2 is required for molecular interaction with immunosuppressant FK-506 binding protein 38 (FKBP38)". FEBS Lett. 579 (6): 1469–76. doi:10.1016/j.febslet.2005.01.053. PMID 15733859. S2CID 19114701.
Weiwad M, Edlich F, Erdmann F, et al. (2005). "A reassessment of the inhibitory capacity of human FKBP38 on calcineurin". FEBS Lett. 579 (7): 1591–6. doi:10.1016/j.febslet.2004.12.098. PMID 15757646. S2CID 12995306.
Edlich F, Weiwad M, Erdmann F, et al. (2005). "Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin". EMBO J. 24 (14): 2688–99. doi:10.1038/sj.emboj.7600739. PMC 1176465. PMID 15990872.
Kang CB, Feng L, Chia J, Yoon HS (2005). "Molecular characterization of FK-506 binding protein 38 and its potential regulatory role on the anti-apoptotic protein Bcl-2". Biochem. Biophys. Res. Commun. 337 (1): 30–8. doi:10.1016/j.bbrc.2005.09.023. hdl:10356/94816. PMID 16176796.
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Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

This article on a gene on human chromosome 19 is a stub. You can help Justapedia by expanding it.

[pmid7543869-1] Lam E, Martin M, Wiederrecht G (Sep 1995). "Isolation of a cDNA encoding a novel human FK506-binding protein homolog containing leucine zipper and tetratricopeptide repeat motifs". Gene. 160 (2): 297–302. doi:10.1016/0378-1119(95)00216-S. PMID 7543869.

[entrez-2] "Entrez Gene: FKBP8 FK506 binding protein 8, 38kDa".

[1]

[2]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

FKBP8

References

Further reading

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