Estradiol hemisuccinate

Estradiol hemisuccinate
Clinical data
Trade names	Eutocol, Hosterona (with progesterone)
Other names	Estradiol succinate; Estradiol 17β-hemisuccinate; Estradiol 17β-succinate
Routes of; administration	By mouth, intramuscular injection
Drug class	Estrogen; Estrogen ester
Identifiers
	IUPAC name 4-{[(17β)-3-Hydroxyestra-1,3,5(10)-trien-17-yl]oxy}-4-oxobutanoic acid;
CAS Number	7698-93-3;
PubChem CID	66440;
PubChem SID	99444362;
DrugBank	DB07891;
ChemSpider	59813;
UNII	VQV5064VG6;
ChEMBL	ChEMBL1233274;
PDB ligand	HE7 (PDBe, RCSB PDB);
Chemical and physical data
Formula	C22H28O5
Molar mass	372.461 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C[C@]12CC[C@@H]3c4ccc(cc4CC[C@H]3[C@@H]1CC[C@@H]2OC(=O)CCC(=O)O)O;
	InChI InChI=1S/C22H28O5/c1-22-11-10-16-15-5-3-14(23)12-13(15)2-4-17(16)18(22)6-7-19(22)27-21(26)9-8-20(24)25/h3,5,12,16-19,23H,2,4,6-11H2,1H3,(H,24,25)/t16-,17-,18+,19+,22+/m1/s1; Key:YJPIDPAGJSWWBE-FNIAAEIWSA-N;

Estradiol hemisuccinate (brand name Eutocol), or simply estradiol succinate, also known as estradiol 17β-hemisuccinate, is an estrogen medication and an estrogen ester – specifically, the hemisuccinate ester of estradiol.^[1] It is used as a component of hormone replacement therapy for menopause.^[2] Like other estrogens, estradiol hemisuccinate has been found to have beneficial effects on the skin, with improvement of skin thickness observed.^[3]^[4]

Estradiol hemisuccinate is also a component of estradiol hemisuccinate/progesterone (brand name Hosterona), an injectable preparation used to induce withdrawal bleeding in women with amenorrhea.^[5]^[6]^[7]

References

^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.
^ Miranda A. Farage; Kenneth W. Miller; Howard I. Maibach (2 December 2009). Textbook of Aging Skin. Springer Science & Business Media. pp. 362–. ISBN 978-3-540-89655-5.
^ Thompson, Zack; Maibach, Howard I. (2010). Biological Effects of Estrogen on Skin. pp. 361–367. doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5.
^ Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". Am. J. Obstet. Gynecol. 170 (2): 642–9. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.
^ https://matchmyrx.com/es/directorio/marca/hosterona
^ "Hosterona - Para qué sirve". 23 November 2012.
^ "HOSTERONA (Hormonoterapia) - Laboratorio GADOR".

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[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. p. 897. ISBN 978-1-4757-2085-3.

[FarageMiller2009-2] Miranda A. Farage; Kenneth W. Miller; Howard I. Maibach (2 December 2009). Textbook of Aging Skin. Springer Science & Business Media. pp. 362–. ISBN 978-3-540-89655-5.

[ThompsonMaibach2010-3] Thompson, Zack; Maibach, Howard I. (2010). Biological Effects of Estrogen on Skin. pp. 361–367. doi:10.1007/978-3-540-89656-2_35. ISBN 978-3-540-89655-5.

[pmid8116726-4] Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, Langevin M (1994). "A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness". Am. J. Obstet. Gynecol. 170 (2): 642–9. doi:10.1016/s0002-9378(94)70242-x. PMID 8116726.

[MatchMyRx-Hosterona-5] ttps://matchmyrx.com/es/directorio/marca/hosterona

[LosMedicamentos-Hosterona-6] "Hosterona - Para qué sirve". 23 November 2012.

[MiVademecum-Hosterona-7] "HOSTERONA (Hormonoterapia) - Laboratorio GADOR".

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v t e Estradiol
Topics	Estradiol (as a hormone) Estradiol (as a medication) Pharmacodynamics of estradiol Pharmacokinetics of estradiol Estrogen (as a hormone) Estrogen (as a medication) Menopausal hormone therapy Feminizing hormone therapy Estradiol-containing birth control pill Combined injectable birth control High-dose estrogen Hydroxylation of estradiol
Esters	Estradiol acetate Estradiol acetylsalicylate Estradiol anthranilate Estradiol benzoate butyrate Estradiol benzoate cyclooctenyl ether Estradiol benzoate Estradiol butyrylacetate Estradiol cyclooctyl acetate Estradiol cypionate Estradiol decanoate Estradiol diacetate Estradiol dibutyrate Estradiol dienantate Estradiol dipropionate Estradiol distearate Estradiol disulfate Estradiol diundecylate Estradiol diundecylenate Estradiol enantate Estradiol furoate Estradiol glucuronide Estradiol hemisuccinate Estradiol hexahydrobenzoate Estradiol monopropionate Estradiol mustard Estradiol palmitate Estradiol phenylpropionate Estradiol phosphate Estradiol pivalate Estradiol propoxyphenylpropionate Estradiol salicylate Estradiol stearate Estradiol sulfamate Estradiol sulfate Estradiol undecylate Estradiol undecylenate Estradiol valerate Estramustine phosphate (estradiol normustine phosphate) Estrogen ester Polyestradiol phosphate
Related	Estrone Estriol Estetrol Ethinylestradiol Conjugated estrogens Esterified estrogens Estrone sulfate Estropipate (piperazine estrone sulfate)

Estradiol hemisuccinate

See also

References

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