David A. Fidock

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David A. Fidock (born 8 December 1965), is the CS Hamish Young Professor of Microbiology and Immunology and Professor of Medical Sciences at Columbia University Irving Medical Center in Manhattan.[1][2][3]

Education

Fidock was born in Paris, on 8 December 1965 and moved to Australia when he was seven years old. He attended the University of Adelaide and earned a bachelor of mathematical sciences and an honors degree in genetics in 1985. He earned a PhD in microbiology and a diploma in medical entomology from the Institut Pasteur in Paris in 1994.[4][5][6]

Research

Fidock's research focuses on the genetic and molecular mechanisms behind antimalarial drug resistance in the human parasite Plasmodium falciparum, as well as target-based drug discovery and development, genetically attenuated vaccinations, and parasite metabolism.[7][8][9] He pioneered the development of methods for genetically modifying malaria parasites and for elucidating the genetic basis of P. falciparum resistance to various first-line medicines (including artemisinin, chloroquine and piperaquine).[10][11][12]

Awards

Publications

  • The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chem Biol (in press).[14]
  • Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. Elife 10: e66277.[15]
  • Inhibition of resistance-refractory P. falciparum kinase PKG delivers prophylactic, blood stage, and transmission-blocking antiplasmodial activity. Cell Chem Biol 27: 806-16.[16]
  • Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13. PLoS Pathog 16: e1008482.[17]
  • Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathog 15: e1007722.[18]
  • Plasmodium falciparum resistance to piperaquine driven by PfCRT. Lancet Infect Dis 19: 1168-9.[19]
  • Structure and drug resistance of the Plasmodium falciparum transporter PfCRT. Nature 576: 315-20.[20]

References

  1. ^ "Faculty - David A. Fidock". Department of Microbiology & Immunology -US. Retrieved 2022-01-04.
  2. ^ "David A. Fidock, PhD". Vagelos College of Physicians and Surgeons. 2017-06-12. Retrieved 2022-01-04.
  3. ^ "David Fidock". scholar.google.com. Retrieved 2022-01-04.
  4. ^ "David A. Fidock, PhD". MD-PhD Program. 12 June 2017. Retrieved 2022-01-04.
  5. ^ "David Fidock | DELGEME". www.delgeme.org. Retrieved 2022-01-04.
  6. ^ "astmh.org" (PDF).{{cite web}}: CS1 maint: url-status (link)
  7. ^ "MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling | Medicines for Malaria Venture". www.mmv.org. Retrieved 2022-01-04.
  8. ^ Blasco, Benjamin; Leroy, Didier; Fidock, David A (2017-08-04). "Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic". Nature Medicine. 23 (8): 917–928. doi:10.1038/nm.4381. ISSN 1078-8956. PMC 5747363. PMID 28777791.
  9. ^ Miguel-Blanco, Celia; Murithi, James M.; Benavente, Ernest Diez; Angrisano, Fiona; Sala, Katarzyna A.; van Schalkwyk, Donelly A.; Vanaerschot, Manu; Schwach, Frank; Fuchter, Matthew J.; Billker, Oliver; Sutherland, Colin J. (2021-01-21). "The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957". Scientific Reports. 11 (1): 1888. doi:10.1038/s41598-021-81343-z. ISSN 2045-2322. PMC 7820608. PMID 33479319.
  10. ^ Duffey, Maëlle; Blasco, Benjamin; Burrows, Jeremy N.; Wells, Timothy N. C.; Fidock, David A.; Leroy, Didier (2021-08-01). "Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials". Trends in Parasitologyglish. 37 (8): 709–721. doi:10.1016/j.pt.2021.04.006. ISSN 1471-4922. PMC 8282644. PMID 34001441.
  11. ^ Ekland, Eric H.; Fidock, David A. (August 2007). "Advances in understanding the genetic basis of antimalarial drug resistance". Current Opinion in Microbiology. 10 (4): 363–370. doi:10.1016/j.mib.2007.07.007. ISSN 1369-5274. PMC 2080794. PMID 17709280.
  12. ^ Miguel-Blanco, Celia; Murithi, James M.; Benavente, Ernest Diez; Angrisano, Fiona; Sala, Katarzyna A.; van Schalkwyk, Donelly A.; Vanaerschot, Manu; Schwach, Frank; Fuchter, Matthew J.; Billker, Oliver; Sutherland, Colin J. (2021-01-21). "The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957". Scientific Reports. 11 (1): 1888. doi:10.1038/s41598-021-81343-z. ISSN 2045-2322. PMC 7820608. PMID 33479319.
  13. ^ "MMV awards Project of the Year 2020 to Professor David Fidock and team for critical contribution to malaria drug resistance profiling - Medicines for Malaria Venture". www.mmv.org. Retrieved 2022-03-16.
  14. ^ Murithi, James M.; Deni, Ioanna; Pasaje, Charisse Flerida A.; Okombo, John; Bridgford, Jessica L.; Gnädig, Nina F.; Edwards, Rachel L.; Yeo, Tomas; Mok, Sachel; Burkhard, Anna Y.; Coburn-Flynn, Olivia (2021-07-06). "The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance". Cell Chemical Biologyglish. 29 (5): S2451-9456(21)00305-6. doi:10.1016/j.chembiol.2021.06.006. ISSN 2451-9456. PMC 8727639. PMID 34233174.{{cite journal}}: CS1 maint: PMC embargo expired (link)
  15. ^ Stokes, Barbara H; Dhingra, Satish K; Rubiano, Kelly; Mok, Sachel; Straimer, Judith; Gnädig, Nina F; Deni, Ioanna; Schindler, Kyra A; Bath, Jade R; Ward, Kurt E; Striepen, Josefine (2021-07-19). Soldati-Favre, Dominique (ed.). "Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness". eLife. 10: e66277. doi:10.7554/eLife.66277. ISSN 2050-084X. PMC 8321553. PMID 34279219.
  16. ^ Vanaerschot, Manu; Murithi, James M.; Pasaje, Charisse Flerida A.; Ghidelli-Disse, Sonja; Dwomoh, Louis; Bird, Megan; Spottiswoode, Natasha; Mittal, Nimisha; Arendse, Lauren B.; Owen, Edward S.; Wicht, Kathryn J. (2020-07-16). "Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity". Cell Chemical Biologyglish. 27 (7): 806–816.e8. doi:10.1016/j.chembiol.2020.04.001. ISSN 2451-9456. PMC 7369637. PMID 32359426.
  17. ^ Gnädig, Nina F.; Stokes, Barbara H.; Edwards, Rachel L.; Kalantarov, Gavreel F.; Heimsch, Kim C.; Kuderjavy, Michal; Crane, Audrey; Lee, Marcus C. S.; Straimer, Judith; Becker, Katja; Trakht, Ilya N. (2020-04-20). "Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13". PLOS Pathogens. 16 (4): e1008482. doi:10.1371/journal.ppat.1008482. ISSN 1553-7374. PMC 7192513. PMID 32310999.
  18. ^ Stokes, Barbara H.; Yoo, Euna; Murithi, James M.; Luth, Madeline R.; Afanasyev, Pavel; Fonseca, Paula C. A. da; Winzeler, Elizabeth A.; Ng, Caroline L.; Bogyo, Matthew; Fidock, David A. (2019-06-06). "Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents". PLOS Pathogens. 15 (6): e1007722. doi:10.1371/journal.ppat.1007722. ISSN 1553-7374. PMC 6553790. PMID 31170268.
  19. ^ Dhingra, Satish K.; Small-Saunders, Jennifer L.; Ménard, Didier; Fidock, David A. (2019-11-01). "Plasmodium falciparum resistance to piperaquine driven by PfCRT". The Lancet Infectious Diseasesglish. 19 (11): 1168–1169. doi:10.1016/S1473-3099(19)30543-2. ISSN 1473-3099. PMC 6943240. PMID 31657776.
  20. ^ Kim, Jonathan; Tan, Yong Zi; Wicht, Kathryn J.; Erramilli, Satchal K.; Dhingra, Satish K.; Okombo, John; Vendome, Jeremie; Hagenah, Laura M.; Giacometti, Sabrina I.; Warren, Audrey L.; Nosol, Kamil (December 2019). "Structure and drug resistance of the Plasmodium falciparum transporter PfCRT". Nature. 576 (7786): 315–320. doi:10.1038/s41586-019-1795-x. ISSN 1476-4687. PMC 6911266. PMID 31776516.

External links

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