Copper fist

Copper fist domain
Structure of a zinc domain conserved in yeast copper-regulated transcription factors.
Identifiers
Symbol	Copper fist
Pfam	PF00649
InterPro	IPR001083
SMART	SM00412
PROSITE	PS50073
SCOP2	1co4 / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1co4​

Copper fist is an N-terminal domain involved in copper-dependent DNA binding. It is named for its resemblance to a fist.

It can be found in some fungal transcription factors. These proteins activate the transcription of the metallothionein gene in response to copper. Metallothionein maintains copper levels in yeast. The copper fist domain is similar in structure to metallothionein itself, and on copper binding undergoes a large conformational change, which allows DNA binding.

External links

• Copper fist definition