In April 2021, while ranked world No. 180, Osorio won her first singles title at the Copa Colsanitas in her native Colombia, beating Tamara Zidanšek in the final.[1][2] She followed up with a semifinal appearance at the Charleston Open the following week.[3] In May, she reached her third straight clay-court semifinal at the Serbia Open,[4] entering the top 100 as a result.[5]
Osorio completed her first professional season by reaching the final of the Tenerife Open, where she eventually lost to Ann Li. She later revealed in an interview that she sustained an abdominal injury which affected her in the final round of the tournament.[11] Her success at the tournament saw her reach a new career high of 53.[12]
2022: Third WTA Tour final, top-40 and Australian Open debut
Osorio gained direct acceptance at the Monterrey Open. At the tournament, she reached her third WTA Tour-level singles final, losing to second seed and 2021 US Open runner-up, Leylah Fernandez, losing multiple match points in the process.
(W) winner; (F) finalist; (SF) semifinalist; (QF) quarterfinalist; (#R) rounds 4, 3, 2, 1; (RR) round-robin stage; (Q#) qualification round; (P#) preliminary round; (DNQ) did not qualify; (A) absent; (Z#) Davis/Fed Cup Zonal Group (with number indication) or (PO) play-off; (G) gold, (S) silver or (B) bronze Olympic/Paralympic medal; (NMS) not a Masters tournament; (NTI) not a Tier I tournament; (P) postponed; (NH) not held; (SR) strike rate (events won / competed); (W–L) win–loss record.
To avoid confusion and double counting, these charts are updated at the conclusion of a tournament or when the player's participation has ended.
Only main-draw results in WTA Tour, Grand Slam tournaments, Fed Cup/Billie Jean King Cup and Olympic Games are included in win–loss records.[14]
^The first Premier 5 event of the year has switched back and forth between the Dubai Tennis Championships and the Qatar Open since 2009. Dubai was classified as a Premier 5 event from 2009–2011 before being succeeded by Doha for the 2012–2014 period. In 2015, Dubai regained its Premier 5 status while Doha was demoted to Premier status. The two tournaments have since alternated status every year. The Premier 5 tournaments were reclassified as WTA 1000 tournaments in 2021.