Bettie Sue Masters

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Bettie Sue Masters
BettieSueMasters in 2013.jpg
Born(1937-06-13)June 13, 1937
Lexington, Virginia
Alma materDuke University
Scientific career
ThesisThe mechanism of hepatic microsomal triphosphopyridine nucleotide-cytochrome c reductase (1963)

Bettie Sue Siler Masters is an adjunct professor at Duke University known for her work on nitric oxide synthase and cytochrome P450 reductase. She was the 1992 recipient of the FASEB Excellence in Science Award, and has been elected to the National Academy of Medicine and the American Association for the Advancement of Science.

Early life and education

Masters was born in Lexington, Virginia, where her father was a radio announcer and a singer. As a child she was an avid reader of Sherlock Holmes and Dr. Watson whose analytical skills she admired.[1] She became interested in chemistry during her sophomore year in high school, and placed high enough in the Westinghouse Science Talent Search to receive a scholarship for college. After College of William & Mary would not accept the scholarship because she was a woman, she went on to attend Roanoke College, thereby becoming a first-generation college student.[1] She graduated from Roanoke College in 1959.[2] In 1963 she earned her Ph.D. from Duke University.[3]

Career

Following her Ph.D. she conducted postdoctoral research first with the American Cancer Society and then with the American Heart Association.[2][1] In 1968 she moved to the University of Texas Southwestern Medical School where she started her research lab.[2][4] In 1982 she moved to the Medical College of Wisconsin to accept the position as chair of the department of biochemistry, thereby becoming the first woman to hold this position.[2] In 1990 she moved to the University of Texas Health Science Center at San Antonio where she was named as the Robert A. Welch Distinguished Professor in Chemistry.[2] As of 2022 she is an adjunct professor at Duke University.[4]

Research

Masters is known for her work on the structure and function of enzymes. As a graduate student she characterized nicotinamide adenine dinucleotide phosphate (NADPH).[5][6] She went on to develop methods to extract enzymes such as cytochrome P450 reductase which allows investigations into their biochemical properties,[7] and definition of the active sites of the protein.[8] For the enzyme nitric oxide synthase she examined shapes of the enzyme, the metals located within the protein,[9] and the co-factors of nitric oxide synthase.[10]

Selected publications

Awards and honors

In 1992 Masters received the Excellence in Science Award from the Federation of American Societies for Experimental Biology (FASEB), and in 2000 she was the recipient of the Bernard B. Brodie Award from the American Society for Pharmacology and Experimental Therapeutics. She was elected to the National Academy of Medicine in 1996,[11] and in 2001 she was named a fellow of the American Association for the Advancement of Science.[2][12] In 2005, Charles University awarded Masters an honorary degree in recognition of her work.[1]

References

  1. ^ a b c d Masters, Bettie Sue Siler (2009). "A Professional and Personal Odyssey". Journal of Biological Chemistry. 284 (30): 19765–19780. doi:10.1074/jbc.x109.007518. ISSN 0021-9258. PMC 2740401. PMID 19398561.
  2. ^ a b c d e f "Dr. Bettie S. Masters '59 | Roanoke College". www.roanoke.edu. Retrieved 2022-06-17.
  3. ^ Masters, Bettie Sue Siler (1963). The mechanism of hepatic microsomal triphosphopyridine nucleotide-cytochrome c reductase ... (Thesis). OCLC 21574619.
  4. ^ a b "Bettie Sue Masters, PhD | Duke Department of Biochemistry". www.biochem.duke.edu. Retrieved 2022-06-17.
  5. ^ MASTERS, B S; KAMIN, H; GIBSON, Q H; WILLIAMS, C H (1965-02-01). "Studies on the Mechanism of Microsomal Triphosphopyridine Nucleotide-Cytochrome C Reductase". The Journal of Biological Chemistry. 240 (2): 921–931. doi:10.1016/S0021-9258(17)45262-8. ISSN 1083-351X. PMID 14275154.
  6. ^ Masters, Bettie Sue Siler; Bilimoria, Minoo H.; Kamin, Henry; Gibson, Quentin H. (1965). "The Mechanism of 1- and 2-Electron Transfers Catalyzed by Reduced Triphosphopyridine Nucleotide-Cytochrome c Reductase". Journal of Biological Chemistry. 240 (10): 4081–4088. doi:10.1016/s0021-9258(18)97152-8. ISSN 0021-9258. PMID 4378860.
  7. ^ Yasukochi, Y; Masters, B S (1976). "Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography". Journal of Biological Chemistry. 251 (17): 5337–5344. doi:10.1016/s0021-9258(17)33166-6. ISSN 0021-9258. PMID 821951.
  8. ^ Wang, Ming; Roberts, David L.; Paschke, Rosemary; Shea, Thomas M.; Masters, Bettie Sue Siler; Kim, Jung-Ja P. (1997-08-05). "Three-dimensional structure of NADPH–cytochrome P450 reductase: Prototype for FMN- and FAD-containing enzymes". Proceedings of the National Academy of Sciences. 94 (16): 8411–8416. Bibcode:1997PNAS...94.8411W. doi:10.1073/pnas.94.16.8411. ISSN 0027-8424. PMC 22938. PMID 9237990.
  9. ^ Raman, C.S; Li, Huiying; Martásek, Pavel; Král, Vladimir; Masters, Bettie Sue S; Poulos, Thomas L (1998). "Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase". Cell. 95 (7): 939–950. doi:10.1016/s0092-8674(00)81718-3. ISSN 0092-8674. PMID 9875848. S2CID 2838840.
  10. ^ Vásquez-Vivar, Jeannette; Kalyanaraman, B.; Martásek, Pavel; Hogg, Neil; Masters, Bettie Sue Siler; Karoui, Hakim; Tordo, Paul; Pritchard, Kirkwood A. (1998-08-04). "Superoxide generation by endothelial nitric oxide synthase: The influence of cofactors". Proceedings of the National Academy of Sciences. 95 (16): 9220–9225. Bibcode:1998PNAS...95.9220V. doi:10.1073/pnas.95.16.9220. ISSN 0027-8424. PMC 21319. PMID 9689061.
  11. ^ "Bettie Sue Masters, Ph.D., D.Sc., M.D. (Hon.)". National Academy of Medicine. Retrieved 2022-06-17.
  12. ^ "Historic Fellows | American Association for the Advancement of Science". www.aaas.org. Retrieved 2022-06-17.
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