Ali Rezai (neurosurgeon)

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Ali Rezai is a neurosurgeon interested in advancing the use of brain chip implants in deep brain stimulation and neuromodulation to treat Parkinson's disease, obsessive–compulsive disorder, Alzheimer's disease and traumatic brain injury.[1][2][3][4]

In 2014 Rezai was a member of a surgical team who implanted a chip developed by Battelle Research Institute[5] to decode and transmit signals from the motor cortex of a patient's brain to bypass spinal injury and restore limb movement. Although the patient did not achieve functional use of the hand, the approach provided movement to his hand. This surgical procedure was purported to be a technological and breakthrough in neural engineering as the first ever account of "limb reanimation."[6][7][8][9]

Rezai is the executive chairman and director of the Rockefeller Neuroscience Institute at West Virginia University.[10][11] He is the former director of Ohio State University's Neurological Institute and the university's Stanley D. and Joan H. Ross Chair in Neuromodulation and professor of neurosurgery and neuroscience.[4]

Deep Brain Stimulation Technology

For over a decade, the technology of deep brain stimulation has been applied to treat patients with Parkinson's disease[11] and other movement disorders.

The safety and efficacy of deep brain stimulation is also being widely studied at the ventral capsule/ventral striatum region to specifically modulate frontal lobe behavioral and cognitive networks as a novel treatment approach for Alzheimer's disease patients.[12][13]

On Nov. 1, 2019, Rezai was a member of a team that surgically implanted a deep brain stimulator chip into the nucleus accumbens part of the human brain to reduce human cravings for drugs, particularly opioids.[14] This marked the first time that deep brain stimulation was performed in the United States for drug addiction.[15] The procedure, approved by the US Food and Drug Administration, received funding from the National Institute on Drug Abuse. The patient, Gerod Buckhalter, age 33, was a drug abuser since age 15 and the first of four patients in this pilot program aimed at a small percentage of patients with treatment-resistant cravings for opioids. The operation was a first-in-the-US clinical trial using deep brain stimulation for patients with treatment-resistant opioid use disorder.[16]

Innovations

On November 15, 2018, a team of approximately eight medical investigators at The Rockefeller Neuroscience Institute at West Virginia University conducted the nation's first phase III clinical trial using a tiny, pill-like micropellet implant made of a non-addictive, non-steroid medication that was placed into a patient's lower back to combat chronic pain caused from sciatica.[17][18][19]

Research

Education

Rezai received an undergraduate degree from the University of California, Los Angeles, and graduated with honors from the University of Southern California's School of Medicine to earn his MD degree in 1990. He completed his subspecialty training in functional neurosurgery at the University of Toronto. In 1997, Rezai completed the residency program at New York University's School of Medicine.

Career

From 2011 to 2013, Rezai was president of the North American Neuromodulation Society. He is a past president of the Congress of Neurological Surgeons and the American Society of Stereotactic and Functional Neurosurgery.[24][25] In September 2017, Rezai was appointed by West Virginia University and the Rockefeller family as the incoming director to lead neuroscience clinical studies and research for the new West Virginia University Rockefeller Neuroscience Institute.[26][4]

Honors and Awards

Editorial Positions

Professional Society Positions

  • President, North American Neuromodulation Society, 2011–2013[28]
  • President, Congress of Neurological Surgeons, 2012–2013[4]
  • Past president, American Society of Stereotactic and Functional Neurosurgery, June 2010–June 2012[4]
  • Annual Meeting Scientific Program chairman, North American Neuromodulation Society Meeting, 2009–2011
  • Annual Meeting Program chairman, Congress of Neurological Surgeons Annual Meeting, 2010
  • Vice-president, American Society of Stereotactic and Functional Neurosurgery (2008–2010)
  • Executive Committee, Congress of Neurological Surgeons, 2002–2013
  • Board of Directors, North American Neuromodulation Society, 2004–2013
  • Board of Directors, International Society of Reconstructive Neurosurgery, 2005–2013

Published Works

Rezai has published more than 175 peer-reviewed articles in peer reviewed journals, including Nature and Lancet Neurology. He serves on the editorial board of five scientific journals, including Neurosurgery.[24]

Special Presentations

  • "Brain Pacemakers" Presentation to the President of the United States, George W. Bush, July 10, 2007[29]
  • "Traumatic Brain Injury: Diagnosis and Treatment" Presentation on Capitol Hill to members of the United States Senate and House of Representatives, June 27, 2007
  • "Deep Brain Stimulation." Presentation to Ohio Governor Ted Strickland. Cleveland Clinic, Cleveland, OH, February 7, 2008
  • "Traumatic Brain Injury: Implications" Social Security Administration Hearing, Washington, D.C., November 18, 2008
  • "Neurological Innovations." Presentation to Mayor of Cleveland, Frank G. Jackson, April 6, 2009
  • "Neuromodulation Overview." Presentation to Ohio Governor John Kasich, Ohio State University Medical Center, Columbus, OH, December 2, 2011
  • "Neuromodulation and chronic disease" Presentation to the Cabinet of the Governor of Ohio. Ohio Statehouse, Columbus, OH, January 20, 2012

References

  1. ^ Editor, By Peggy Peck MedPage Today Managing. "CNN.com - Doctor's specialty is re-wiring brain - Mar 22, 2006". www.CNN.com. Archived from the original on 29 April 2015. Retrieved 7 November 2017. {{cite web}}: |last= has generic name (help)
  2. ^ Bouton, Chad E.; Shaikhouni, Ammar; Annetta, Nicholas V.; Bockbrader, Marcia A.; Friedenberg, David A.; Nielson, Dylan M.; Sharma, Gaurav; Sederberg, Per B.; Glenn, Bradley C.; Mysiw, W. Jerry; Morgan, Austin G.; Deogaonkar, Milind; Rezai, Ali R. (13 April 2016). "Restoring cortical control of functional movement in a human with quadriplegia". Nature. 533 (7602): 247–250. Bibcode:2016Natur.533..247B. doi:10.1038/nature17435. PMID 27074513. S2CID 205248450.
  3. ^ a b Ghose, Carrie (July 8, 2016). "PHOTOS: Inside the operating room with Ohio State's Dr. Ali Rezai during deep brain stimulation (Video)". www.bizjournals.com. Archived from the original on 2020-01-10. Retrieved 2021-11-22.
  4. ^ a b c d e Buchanan, Doug; Federoff, Stacey (September 29, 2017) [September 28, 2017]. "Ohio State neurosurgeon Ali Rezai leaving for West Virginia University". www.bizjournals.com. Archived from the original on April 14, 2020. Retrieved 2021-11-22.
  5. ^ Battelle Research Institute
  6. ^ Carey, Benedict (13 April 2016). "Chip, Implanted in Brain, Helps Paralyzed Man Regain Control of Hand". The New York Times. Archived from the original on 2 April 2019. Retrieved 7 November 2017.
  7. ^ Ghose, Carrie (July 8, 2016). "Ohio State's Ali Rezai: At the outer reaches of neuroscience, the search to end suffering". www.bizjournals.com. Archived from the original on 2016-07-09. Retrieved 2021-11-22.
  8. ^ "Neurobridge device allows quadriplegic to move his own hand". CNET.com. Archived from the original on 23 October 2017. Retrieved 7 November 2017.
  9. ^ Tankersley, Jim (29 April 2014). "The 'bionic age' dawns in an Ohio hospital, with a chip aimed at giving a paralyzed man the use of his hands". Archived from the original on 2 April 2019. Retrieved 7 November 2017 – via www.WashingtonPost.com.
  10. ^ Federoff, Stacey (September 28, 2017). "WVU forms new neuroscience institute". www.bizjournals.com. Archived from the original on 2021-11-22. Retrieved 2021-11-22.
  11. ^ a b "High Tech procedure giving W.Va. Patients 'pace maker' for the brain". Archived from the original on 2018-07-28. Retrieved 2018-07-27.
  12. ^ Scharre, Douglas W.; Weichart, Emily; Nielson, Dylan; Zhang, Jun; Agrawal, Punit; Sederberg, Per B.; Knopp, Michael V.; Rezai, Ali R.; Alzheimer's Disease Neuroimaging Initiative (2018). "Deep Brain Stimulation of Frontal Lobe Networks to Treat Alzheimer's Disease". Journal of Alzheimer's Disease. 62 (2): 621–633. doi:10.3233/JAD-170082. PMID 29400666. Archived from the original on 2018-07-28. Retrieved 2018-07-27.
  13. ^ Knapton, Sarah (30 January 2018). "Brain 'pacemaker' for Alzheimer's helps give life back to patients". The Telegraph. Archived from the original on 28 July 2018. Retrieved 27 July 2018.
  14. ^ "Deep brain stimulation is being tested to treat opioid addiction". Washington Post. ISSN 0190-8286. Archived from the original on 2021-06-29. Retrieved 2021-11-22.
  15. ^ "Brain implants used to fight drug addiction in US". BBC News. 8 November 2019. Archived from the original on 9 November 2019. Retrieved 8 November 2019.
  16. ^ "Institute first in U.S. To use deep brain stimulation to fight opioid addiction". Archived from the original on 2019-11-08. Retrieved 2019-11-08.
  17. ^ "WVU leading nation with potentially 'game changing' opioid addiction, Alzheimer's research". Archived from the original on 2018-11-20. Retrieved 2018-11-20.
  18. ^ "Neuroscience Institute at WVU launches trial on implant for chronic pain". Archived from the original on 2018-11-19. Retrieved 2018-11-20.
  19. ^ "WVU to conduct clinical trial of non-opioid treatment for Sciatica". Archived from the original on 2018-11-20. Retrieved 2018-11-20.
  20. ^ "Could new WVU study lead to Alzheimer's cure?". Archived from the original on 2018-09-22. Retrieved 2018-09-25.
  21. ^ https://www.wboy.com/news/wvu-prepares-to-launch-alzheimer-s-trial/1439918119[bare URL]
  22. ^ "Archived copy". Archived from the original on 2018-11-09. Retrieved 2018-11-08.{{cite web}}: CS1 maint: archived copy as title (link)
  23. ^ "Brain-zapping pacemaker implant could be a new treatment for opioid addiction". Archived from the original on 2018-11-09. Retrieved 2018-11-08.
  24. ^ a b "Ali Rezai, MD - Ohio State Neurological Institute Researchers". WexnerMedical.OSU.edu. Archived from the original on 2 June 2017. Retrieved 7 November 2017.
  25. ^ stormtrooper (12 March 2014). "Ali Rezai - President". www.CNS.org. Archived from the original on 26 September 2018. Retrieved 7 November 2017.
  26. ^ "WVU Medicine and Rockefeller family announce new neurosciences institute - WVU Medicine". WVUMedicine.org. 6 August 2015. Archived from the original on 26 September 2018. Retrieved 7 November 2017.
  27. ^ "Neuromodulation :: Editors". Archived from the original on 2021-01-25. Retrieved 2018-11-08.
  28. ^ a b "Ali R Rezai". 10 February 2014. Archived from the original on 8 November 2018. Retrieved 8 November 2018.
  29. ^ "Region to lose a top brain researcher when Dr. Ali Rezai departs for Ohio State University". 16 June 2009. Archived from the original on 14 November 2018. Retrieved 13 November 2018.
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