Perfluorobutanoic acid

HFBA can also refer to Hebrew Free Burial Association

Perfluorobutanoic acid

Names
Preferred IUPAC name Heptafluorobutanoic acid
Other names Perfluorobutanoic acid Perfluorobutyric acid Heptafluorobutyric acid HFBA PFBA C4 PFCA
Identifiers
CAS Number	375-22-4 Y
3D model (JSmol)	Interactive image
Abbreviations	HFBA
ChEBI	CHEBI:39426 N
ChemSpider	9394 N
PubChem CID	9777
UNII	12VHZ8L29I Y
InChI InChI=1S/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13) N Key: YPJUNDFVDDCYIH-UHFFFAOYSA-N N InChI=1/C4HF7O2/c5-2(6,1(12)13)3(7,8)4(9,10)11/h(H,12,13) Key: YPJUNDFVDDCYIH-UHFFFAOYAI
SMILES OC(C(F)(F)C(F)(F)C(F)(F)F)=O
Properties
Chemical formula	C4HF7O2
Molar mass	214.039 g·mol−1
Appearance	colourless liquid
Density	1.64 g/ml
Boiling point	120 °C (248 °F; 393 K)
Solubility in water	high
Hazards
Occupational safety and health (OHS/OSH):
Main hazards	strong acid
GHS labelling:
Pictograms
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260, P280, P303+P361+P353, P304+P340+P310, P305+P351+P338
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

Perfluorobutanoic acid (PFBA) is a perfluoroalkyl carboxylic acid with the formula C₃F₇CO₂H. As the perfluorinated derivative of butyric acid, this colourless liquid is prepared by electrofluorination of the corresponding butyryl fluoride.

Applications

PFBA has a variety of niche applications in analytical and synthetic chemistry. It is an ion pair reagent for reverse-phase HPLC. It is used in the sequencing, synthesis, and solubilizing of proteins and peptides.

Esters derived from PFBA readily undergo condensation, owing to their electrophilicity. Specialized ligands for metal ions are generated capitalizing on this property, such as Eufod.