File:Repro4 mutation in Spermatocytes.jpg

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Author	Fengyun Sun and Mary Ann Handel *
Short title	A Mutation in Mtap2 Is Associated with Arrest of Mammalian Spermatocytes before the First Meiotic Division
Image title	In spite of evolutionary conservation of meiosis, many of the genes that control mammalian meiosis are still unknown. We report here that the ENU-induced repro4 mutation, identified in a screen to uncover genes that control mouse meiosis, causes failure of spermatocytes to exit meiotic prophase I via the G2/MI transition. Major events of meiotic prophase I occurred normally in affected spermatocytes and known regulators of the meiotic G2/MI transition were present and functional. Deep sequencing of mutant DNA revealed a mutation located in an intron of the Mtap2 gene, encoding
JPEG file comment	In spite of evolutionary conservation of meiosis, many of the genes that control mammalian meiosis are still unknown. We report here that the ENU-induced repro4 mutation, identified in a screen to uncover genes that control mouse meiosis, causes failure of spermatocytes to exit meiotic prophase I via the G2/MI transition. Major events of meiotic prophase I occurred normally in affected spermatocytes and known regulators of the meiotic G2/MI transition were present and functional. Deep sequencing of mutant DNA revealed a mutation located in an intron of the Mtap2 gene, encoding
Date and time of digitizing	14:52, 10 January 2011
Software used	Microsoft® Office Word 2007
File change date and time	21:07, 2 October 2012
Date metadata was last modified	21:07, 2 October 2012
Keywords	meiosis; spermatogenesis; microtubule-associated protein
Unique ID of original document	uuid:8cef5a49-6d67-4bfe-a276-60ba1c0978bf
Copyright status	Copyright status not set

File:Repro4 mutation in Spermatocytes.jpg

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