DescriptionAdenoviral NIS gene expression in a mouse tumour.jpg
English: SPECT/CT images of a cross-section of the lungs showing radioiodide accumulation into tumor (located by the crosshairs) in the lungs of a mouse treated intravenously with Ad5/3-hTERT-hNIS and intraperitoneally with radioiodide (left), and a control mouse treated only intraperitoneally with radioiodide (Right).
English: Citation: Rajecki M, Sarparanta M, Hakkarainen T, Tenhunen M, Diaconu I, et al. (2012) SPECT/CT Imaging of hNIS -Expression after Intravenous Delivery of an Oncolytic Adenovirus and 131I. PLoS ONE 7(3): e32871. doi:10.1371/journal.pone.0032871
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<title>Increasing amount of<sup>123</sup>I<sup>−</sup>accumulates in the tumor over time showing progressive virus replication and increasing tumor hNIS-expression.</title><p>(<bold>a</bold>) SPECT/CT image (sagittal section) showing<sup>123</sup>I<sup>−</sup>accumulation into tumor in the lungs of a mouse treated intravenously with Ad5/3-hTERT-hNIS and intraperitoneally with<sup>131</sup>I<sup>−</sup>. (<bold>b</bold>) Control mouse treated with<sup>131</sup>I<sup>−</sup>only shows no<sup>123</sup>I<sup>−</sup>-accumulation in the lungs on the course of the treatment. (<bold>c</bold>) Transverse section of the lungs of the mouse shown in (<bold>a</bold>) shows accumulation of<sup>123</sup>I<sup>−</sup>into the tumor on the third treatment week. (<bold>d</bold>) Transverse section of lungs of the mouse shown in (<bold>b</bold>) shows no accumulation of<sup>123</sup>I<sup>−</sup>into the tumor on the third treatment week. The crossing point of red lines indicates tumor localization.</p>