Brian Hanley (microbiologist)

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Brian Hanley
NationalityAmerican
OccupationCEO of Butterfly Sciences

Brian Hanley (born c. 1957) is an American microbiologist and founder of Butterfly Sciences. He is known for self-experimenting with gene therapy to try to improve health span.[1][2]

Biography

Hanley obtained a PhD in Microbiology from University of California, Davis in 2009.[3][failed verification][4][5] The same year, he founded Butterfly Sciences in Davis, California to develop a gene therapy to treat HIV AIDS using a combination of GHRH[6] and an intracellular vaccine.[5][7]

Self-experimentation

Hanley said that when he could not raise money for Butterfly, he decided to obtain proof of concept by testing the gene therapy on himself. He said that he designed the plasmid containing a gene coding for growth hormone–releasing hormone and had it made by a scientific supply company for around $10,000.[2] However, the total cost of development was over $500,000.[8]

He said that he corresponded with the FDA prior to starting his self-experimentation, and that the FDA told him he needed to file and get approval for an Investigational New Drug (IND) application before he tested the plasmid on a person; not having obtained an IND, he proceeded without it.[2]

He submitted his protocol to a private institutional review board (IRB), the Institute of Regenerative and Cellular Medicine in Santa Monica, California, which advised on his proposed clinical research plans.[2]

A physician assisted in administration of the plasmid to Hanley's thigh using electroporation.[2] The plasmids were administered twice: once in summer 2015 and a second larger dose in July 2016.[2][9][10]

Hanley claims the treatment has helped him.[9][11] The results were published in December 2021.[12]

See also

References

  1. ^ "GHRH plasmid gene therapy for aging". Retrieved 13 November 2017.
  2. ^ a b c d e f Regalado, Antonio. "One man's quest to hack his own genes". MIT Technology Review. Retrieved 23 April 2017.
  3. ^ "Brian Hanley". Institute for Ethics and Emerging Technologies. Retrieved 23 April 2017.
  4. ^ "Brian Hanley - Info". ResearchGate. Retrieved 23 April 2017.
  5. ^ a b "Company | Butterfly Sciences". bf-sci.com. Retrieved 23 April 2017.
  6. ^ "Company: GHRH plasmid gene therapy for aging - lower part of page". Retrieved 13 November 2017.
  7. ^ "Company: Synthetic intra-cellular HIV vaccine". Retrieved 13 November 2017.
  8. ^ Paul Tullis. "Are You Rich Enough To Live Forever?". Town & Country. Retrieved 12 February 2017.
  9. ^ a b Friend, Tad (3 April 2017). "Silicon Valley's Quest to Live Forever". The New Yorker. Retrieved 23 April 2017.
  10. ^ Giuliano Aluffi (12 February 2017). "Scienziato transgenico per l'elisir di lunga vita: "Così ho modificato le mie cellule"". Repubblica.it (in Italian). Retrieved 23 April 2017.
  11. ^ Brian Hanley (30 May 2017). "Status of the GHRH gene therapy project". Butterfly Sciences. Retrieved 20 Nov 2017.[permanent dead link]
  12. ^ Hanley, Brian P.; Brewer, Keith; Church, George (1 December 2021). "Results of a 5-Year N-of-1 Growth Hormone Releasing Hormone Gene Therapy Experiment". Rejuvenation Research. 24 (6): 424–433. doi:10.1089/rej.2021.0036. PMID 34841890. S2CID 244713959.

External links

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