Andrew D. Huberman
Andrew D. Huberman
|Born||September 26, 1975|
Palo Alto, California, U.S.
|Citizenship||United States of America|
|Alma mater||University of California, Davis (PhD)|
University of California, Berkeley (M.A.)
University of California, Santa Barbara (B.A.)
|Awards||McKnight Foundation Neuroscience Scholar Award (2013)|
Pew Charitable Trusts Biomedical Scholar Award (2013)
ARVO Cogan Award (2017)
|Institutions||Stanford University, University of California, San Diego|
|Doctoral advisor||Barbara Chapman|
|Influences||Ben Barres, Richard Feynman, Oliver Sacks|
Andrew D. Huberman (born September 26, 1975 in Palo Alto, California) is an American neuroscientist and tenured professor in the Department of Neurobiology at the Stanford University School of Medicine where he has made contributions to brain development, brain plasticity, neural regeneration and repair fields. Much of his work has been focused on the visual system, including the mechanisms controlling light-mediated activation of the circadian and autonomic arousal centers in the brain, as well as brain control over conscious vision or sight. Huberman has been credited with coining the term "Non-Sleep Deep Rest" (NSDR), referring to practices that place the brain and body into shallow sleep to accelerate neuroplasticity and help offset mental and physical fatigue.
In 2021, Huberman launched the Huberman Lab podcast, which quickly gained notability in the world of science communication. On his podcast, spanning several hours per episode, Huberman delves into various research topics, both within and outside his expertise, providing listeners with valuable insights into the state of scientific exploration. By 2023, the podcast was ranked as the 6th most popular podcast in the United States on Spotify platforms.
Huberman graduated from Henry M. Gunn High School in 1993. He received a B.A. from the University of California, Santa Barbara, in 1998, an M.A. from the University of California, Berkeley, in 2000, and a PhD in neuroscience from the University of California, Davis, in 2004.
Graduate and postdoctoral research
From 1998–2000, Huberman worked in the laboratory of Irving Zucker, as well as working with Marc Breedlove, at University of California, Berkeley, as part of a team that defined how early androgen exposure impacts development, and he performed the first experiments defining the structure of binocular visual pathways that set the circadian clock in the hypothalamus. From 2000-2004, working as a PhD student in the laboratory of Barbara Chapman at the Center for Neuroscience at the University of California, Davis, Huberman discovered that neural activity and axon guidance molecules work in concert to ensure proper wiring of binocular maps in the brain. Huberman was a Helen Hay Whitney postdoctoral fellow researcher in the laboratory of Ben A. Barres from 2005 to 2010.
Huberman was an assistant professor of neurobiology and neuroscience at University of California, San Diego, from 2011 to 2015. His lab pioneered using genetic tools to study the visual system function, development and disease. Among the Huberman Lab's discoveries was the finding that specific types of retinal neurons degenerate early in glaucoma a common blinding disease depleting sight in over 70 million people, for which there is no cure.
After moving to Stanford in 2016, Huberman discovered and published the use of non-invasive methods such as visual stimulation can enhance regeneration of damaged retinal neurons, leading to partial recovery from blindness, especially when the stimulation is paired with specific forms of gene therapy. The work was covered by mainstream media, including Time magazine and Scientific American. The research was supported in part by the National Eye Institute's Audacious Goals Initiative to restore vision to the blind. The Huberman Lab extended those findings to develop a human clinical trial using virtual reality technology to stimulate regeneration and plasticity of damaged retinal and other visual system neurons.
In 2017, the Huberman Lab created a virtual reality platform for probing the neural mechanisms underlying pathological fear and anxiety. That work involved collecting 360-degree video of various fear inducing scenarios such as heights and claustrophobia as well as atypical fear inducing situations such as swimming with great white sharks. The Huberman VR platform is aimed at making discoveries that will lead to developing new tools for humans to adjust their state in order to promote adaptive coping with stress. The first installment of that work was published in Current Biology, in 2021 as a collaboration with neurosurgeon and neuroscientist Edward Chang (UCSF), wherein they reported that specific patterns of insular cortex brain activity correlate with and may predict anxiety responses.
In May, 2018, Huberman Laboratory published an article in the journal Nature reporting their discovery of two new mammalian brain circuits: one that promotes fear and paralysis, and another that promotes "courageous"/confrontational reaction, to visually-evoked threats. That discovery prompted the now ongoing exploration of how these brain regions may be involved in humans suffering from anxiety-related disorders such as phobias and generalized anxiety.
In 2020, Huberman Lab initiated a collaboration with the laboratory of David Spiegel in the Stanford Department of Psychiatry and Behavioral Sciences, to systematically study how particular patterns of respiration (i.e., breathing/breathwork) and the visual system influence the autonomic nervous system, stress, and other brain states, including sleep.
Honors and awards
- McKnight Foundation Scholar
- Pew Biomedical Scholar
- Catalyst for a Cure Team Member
- ARVO Cogan Award for Contributions to Vision Science and Ophthalmology
In 2021, Huberman launched the Huberman Lab podcast. In episodes lasting several hours, Huberman talks about the state of research in a specific topic, both within and outside his specialty. By 2023, the podcast had become the 6th most popular podcast in the US on Spotify platforms, while his YouTube channel had 3.5 million subscribers and his Instagram account 4.2 million. He was originally inspired to start the podcast after his appearance on the Lex Fridman Podcast. The podcast has featured scientists, medical doctors and other well-known podcasters, including Karl Deisseroth, Lex Fridman, Matthew Walker, Robert Sapolsky, Alia Crum, Charles Zuker and Peter Attia.
Huberman's social media communications have been criticized as being akin to biohacking, hyping preliminary results of animal studies as having potential applications for human performance enhancement. The podcast heavily advertises dietary supplements and multivitamins, some of which are promoted directly by Huberman. Huberman has expressed interest in the presidential candidate and anti-vaccination activist Robert F. Kennedy Jr.. Moreover, controversy surrounds his promotion of supplements and multivitamins sold by podcast sponsors, and hyping of unproven preliminary animal studies as evidence for human enhancement.
Huberman has faced criticism, and attracted attention for appearing on the programs of controversial podcast hosts such as Joe Rogan, whose show led to a Spotify boycott in 2022 over controversial remarks about COVID-19 and vaccines. Huberman asserts that Rogan is genuinely committed to facilitating discussions about science and clarifies that his guest appearances should not be seen as endorsements. Additionally, in a June Instagram comment, Huberman expressed his interest in listening to an episode of Rogan's podcast featuring Robert F. Kennedy Jr., who is both a 2024 presidential candidate, and has expressed concerns over the use of Thiomersal, a certain mercury-based preservative used in some vaccines. Huberman explained that his comment was meant to commend a candidate's willingness to engage in in-depth discussions on podcasts, and he encourages others to do the same.
- "Stanford Profile".
- Steen, Jeff (2022-03-18). "I Tried Sundar Pichai's Non-Meditation Technique to Curb My Stress. It's 10X Better Than a Morning Routine". Inc.com. Retrieved 2022-03-23.
- Jackson, Sarah. "Google CEO Sundar Pichai says he uses NSDR, or 'non-sleep deep rest,' to unwind. Here's what it is and how it works". Business Insider. Retrieved 2022-03-23.
- Eichenlaub, Jean-Baptiste; Jarosiewicz, Beata; Saab, Jad; Franco, Brian; Kelemen, Jessica; Halgren, Eric; Hochberg, Leigh R.; Cash, Sydney S. (2020-05-05). "Replay of Learned Neural Firing Sequences during Rest in Human Motor Cortex". Cell Reports. 31 (5): 107581. doi:10.1016/j.celrep.2020.107581. ISSN 2211-1247. PMC 7337233. PMID 32375031.
- Spotify. "Podcast Charts". Podcast Charts. Retrieved 2022-12-19.
- "Andrew Huberman | Huberman Lab". hubermanlab.stanford.edu. Retrieved 2021-04-07.
- Williams, T. J.; Pepitone, M. E.; Christensen, S. E.; Cooke, B. M.; Huberman, A. D.; Breedlove, N. J.; Breedlove, T. J.; Jordan, C. L.; Breedlove, S. M. (2000-03-30). "Finger-length ratios and sexual orientation". Nature. 404 (6777): 455–456. Bibcode:2000Natur.404..455W. doi:10.1038/35006555. ISSN 0028-0836. PMID 10761903. S2CID 205005405.
- Muscat, Louise; Huberman, Andrew D.; Jordan, Cynthia L.; Morin, Lawrence P. (2003-11-24). "Crossed and uncrossed retinal projections to the hamster circadian system". The Journal of Comparative Neurology. 466 (4): 513–524. doi:10.1002/cne.10894. ISSN 1096-9861. PMID 14566946. S2CID 9722540.
- Huberman, Andrew D.; Feller, Marla B.; Chapman, Barbara (2008-01-01). "Mechanisms Underlying Development of Visual Maps and Receptive Fields". Annual Review of Neuroscience. 31 (1): 479–509. doi:10.1146/annurev.neuro.31.060407.125533. PMC 2655105. PMID 18558864.
- Huberman, Andrew D; Murray, Karl D; Warland, David K; Feldheim, David A; Chapman, Barbara (2005). "Ephrin-As mediate targeting of eye-specific projections to the lateral geniculate nucleus". Nature Neuroscience. 8 (8): 1013–1021. doi:10.1038/nn1505. PMC 2652399. PMID 16025110.
- Huberman, Andrew D.; Speer, Colenso M.; Chapman, Barbara (2006-10-19). "Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields in v1". Neuron. 52 (2): 247–254. doi:10.1016/j.neuron.2006.07.028. ISSN 0896-6273. PMC 2647846. PMID 17046688.
- Huberman, Andrew D.; Manu, Mihai; Koch, Selina M.; Susman, Michael W.; Lutz, Amanda Brosius; Ullian, Erik M.; Baccus, Stephen A.; Barres, Ben A. (2008-08-14). "Architecture and activity-mediated refinement of axonal projections from a mosaic of genetically identified retinal ganglion cells". Neuron. 59 (3): 425–438. doi:10.1016/j.neuron.2008.07.018. ISSN 1097-4199. PMC 8532044. PMID 18701068. S2CID 1519009.
- Huberman, Andrew D.; Wei, Wei; Elstrott, Justin; Stafford, Ben K.; Feller, Marla B.; Barres, Ben A. (2009-05-14). "Genetic identification of an On-Off direction-selective retinal ganglion cell subtype reveals a layer-specific subcortical map of posterior motion". Neuron. 62 (3): 327–334. doi:10.1016/j.neuron.2009.04.014. ISSN 1097-4199. PMC 3140054. PMID 19447089.
- Dhande, Onkar S.; Estevez, Maureen E.; Quattrochi, Lauren E.; El-Danaf, Rana N.; Nguyen, Phong L.; Berson, David M.; Huberman, Andrew D. (2013-11-06). "Genetic dissection of retinal inputs to brainstem nuclei controlling image stabilization". The Journal of Neuroscience. 33 (45): 17797–17813. doi:10.1523/JNEUROSCI.2778-13.2013. ISSN 1529-2401. PMC 3818553. PMID 24198370.
- El-Danaf, Rana N.; Huberman, Andrew D. (2015-02-11). "Characteristic patterns of dendritic remodeling in early-stage glaucoma: evidence from genetically identified retinal ganglion cell types". The Journal of Neuroscience. 35 (6): 2329–2343. doi:10.1523/JNEUROSCI.1419-14.2015. ISSN 1529-2401. PMC 6605614. PMID 25673829.
- Lim, Jung-Hwan A; Stafford, Benjamin K; Nguyen, Phong L; Lien, Brian V; Wang, Chen; Zukor, Katherine; He, Zhigang; Huberman, Andrew D (2016). "Neural activity promotes long-distance, target-specific regeneration of adult retinal axons". Nature Neuroscience. 19 (8): 1073–1084. doi:10.1038/nn.4340. PMC 5708130. PMID 27399843.
- Park, Alice (2016-07-11). "Researchers Help Blind Mice to See for First Time". Time. Retrieved 2023-10-29.
- Weintraub, Karen (2016-07-11). "Regrown Brain Cells Give Blind Mice a New View". Scientific American. Retrieved 2023-10-29.
- Polosukhina, Aleksandra; Litt, Jeffrey; Tochitsky, Ivan; Nemargut, Joseph; Sychev, Yivgeny; De Kouchkovsky, Ivan; Huang, Tracy; Borges, Katharine; Trauner, Dirk; Van Gelder, Russell N.; Kramer, Richard H. (2012). "Photochemical Restoration of Visual Responses in Blind Mice". Neuron. Elsevier BV. 75 (2): 271–282. doi:10.1016/j.neuron.2012.05.022. ISSN 0896-6273.
- "A daredevil researcher's quest: to restore sight lost to glaucoma using VR". STAT. 2018-07-02. Retrieved 2021-07-26.
- Yilmaz Balban, Melis; Cafaro, Erin; Saue-Fletcher, Lauren; Washington, Marlon J.; Bijanzadeh, Maryam; Lee, A. Moses; Chang, Edward F.; Huberman, Andrew D. (February 2021). "Human Responses to Visually Evoked Threat". Current Biology. 31 (3): 601–612.e3. doi:10.1016/j.cub.2020.11.035. ISSN 0960-9822. PMC 8407368. PMID 33242389. S2CID 227165336.
- Balban, Melis Yilmaz; Cafaro, Erin; Saue-Fletcher, Lauren; Washington, Marlon J.; Bijanzadeh, Maryam; Lee, A. Moses; Chang, Edward F.; Huberman, Andrew D. (2021-02-08). "Human Responses to Visually Evoked Threat". Current Biology. 31 (3): 601–612.e3. doi:10.1016/j.cub.2020.11.035. ISSN 0960-9822. PMC 8407368. PMID 33242389. S2CID 227165336.
- Salay, Lindsey D.; Ishiko, Nao; Huberman, Andrew D. (2018-05-02). "A midline thalamic circuit determines reactions to visual threat". Nature. 557 (7704): 183–189. Bibcode:2018Natur.557..183S. doi:10.1038/s41586-018-0078-2. ISSN 1476-4687. PMC 8442544. PMID 29720647. S2CID 13742480.
- Goldman, Bruce (2017-09-05). "Seeing is believing (unfortunately): A project designed to study visually induced fear". Scope. Retrieved 2021-07-26.
- Wapner, Jessica. "Vision and Breathing May Be the Secrets to Surviving 2020". Scientific American. Retrieved 2021-11-13.
- "The Science of Stress, Calm and Sleep with Andrew Huberman". Youtube. Stanford Alumni. 2020-11-24.
- "The McKnight Foundation". neuroscience.mcknight.org. Archived from the original on 22 March 2016. Retrieved 12 January 2022.
- "Andrew D. Huberman, Ph.D."
- "Catalyst for a Cure 2016 Research Progress".
- "2017 Achievement Award Recipients". arvo.org. Archived from the original on 9 August 2016. Retrieved 12 January 2022.
- Ducharme, Jamie (2023-06-28). "How Andrew Huberman Got America to Care About Science". Time. Retrieved 2023-08-21.
- "Apple Podcasts : United States of America : All Podcasts Podcast Charts - Top". chartable.com. Retrieved 2022-12-19.
- Andrew Huberman: Sleep, Dreams, Creativity, Fasting, and Neuroplasticity | Lex Fridman Podcast #164. Lex Fridman. 28 February 2021. Archived from the original on 14 March 2023. Retrieved 28 March 2023 – via YouTube.
- Dr Lex Fridman: Navigating Conflict, Finding Purpose & Maintaining Drive | Huberman Lab Podcast #100. Andrew Huberman. 28 November 2022. Archived from the original on 14 March 2023. Retrieved 28 March 2023 – via YouTube.
- "Huberman Lab". Huberman Lab. Retrieved 2023-07-11.
- Jarry, Jonathan (7 April 2023). "Andrew Huberman Has Supplements on the Brain". McGill University Office for Science and Society. Retrieved 2023-06-15.
- Ducharme, Jamie (2023-06-28). "How Andrew Huberman Got America to Care About Science". Time. Retrieved 2023-10-26.